Supplements in the News

Probiotics Help Restore Alcoholic Damage
 
Published Monday, April 28, 2008

LONDON—An open-label study at The Institute of Hepatology suggested probiotics restore neutrophil phagocytic capacity in alcoholic cirrhosis (J Hepat. 2008) (DOI: 10.1016/j.jhep.2008.02.015). Twelve patients with alcoholic cirrhosis received Lactobacillus casei Shirota three times daily for four weeks. Data was compared to healthy controls (n=13) and cirrhotic patients (n=8) who did not receive probiotics. Baseline neutrophil phagocytic capacity in patients was significantly lower compared to healthy controls, but it normalized at the end of the study. Ex vivo endotoxin-stimulated levels of sTNFR1, sTNFR2 and IL10 were significantly lower at the end of the study (P<0.05). TLR2, 4, and 9 were overexpressed in patients and TLR4 expression normalized by the end of the study. The researchers concluded the data warrants larger, randomized, controlled and mechanistic studies.

 

This abstract provided courtesy of Natural Products Industry Insider, published by Virgo Publishing Inc. 



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