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Pyruvate (the buffered form of pyruvic acid) is a product created in the body during the metabolism of carbohydrates and protein. This supplement has been used in connection with the following health conditions:

  • Obesity - 6 to 10 grams daily combined with an exercise program
    Combining exercise with pyruvate may help speed up your metabolism.
  • Athletic Performance - 100 grams of a combination of dihydroxyacetone and pyruvate
    One group of researchers has reported that a combination of dihydroxyacetone and pyruvate enhanced the endurance of certain muscles.
  • Athletic Performance and Improving Body Composition with Strength Training in Untrained People - Refer to label instructions for dosage
    Three controlled studies of people using a combination of pyruvate and an exercise program reported positive effects on weight loss and body fat

How to Use It
Most human research with pyruvate and weight loss has used at least 30 grams per day. However, such large amounts may not be necessary. In a six-week double-blind trial, as little as 6 grams per day of pyruvate in combination with exercise led to greater weight loss and loss of body fat, compared with a placebo plus exercise. Because it is not an essential nutrient, pyruvate is not associated with a deficiency.

Where to Find It
Pyruvate is formed in the body as a byproduct of the normal metabolism of carbohydrates and protein and is present in several foods, including red apples, cheese, dark beer, and red wine. Dietary supplements of pyruvate are also available.

Side Effects & Interactions
High intakes of pyruvate can trigger gastrointestinal upset, such as gas, bloating, and diarrhea. One preliminary study in exercising women found 10 grams per day of pyruvate reduced blood levels of HDL (the “good” cholesterol) after one month.

At the time of writing, there were no well-known interactions with this supplement.

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